ILC

Ontology Term

innate lymphoid cellCL:0001065

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

ILC

Category

Class of which the cell type is a subclass.

lymphocyteCL:0000542

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

—

Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

KLRB1, IL7R

Canonical Marker Genes

TBX21 (T-bet), IL7RA, KLRB1 (CD161)

Rationale

This cluster was highest in KLRB1, which led us to name them generally ILC's, however it expressed several other strange markers that point to other general lymphocyte functions (ID2, KLRC1, TRDC) or interactions with epithelial cells (KRT86, KRT81)

Inherited from celltype

Set of Labels Description

In this paper we used an automated iterative subclustering algorithm to find hundreds of cell state clusters, after which we merged unsupported clusters and annotated each resulting cluster with a better-known cell subtype. The high-res cell state clusters are annotated as subtype.gene1.gene2, so in some cases we didn't directly name some commonly named subtypes, such as pericytes. When we run DE on the resulting subtypes, we find many canonical and scRNA-suggested marker genes.

Annotation Method

both

Algorithm Name

ARBOL

Algorithm Version

v1.0

Algorithm URL

https://github.com/jo-m-lab/ARBOL/